Determination of relative sensitivity factors for use in spark-source mass spectrometry

by D.C.G. Pearton

Publisher: Council for Mineral Technology in Randburg, South Africa

Written in English
Published: Downloads: 163
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The Physical Object
Pagination9 p.
ID Numbers
Open LibraryOL24707118M

Diagnosing and Resolving Mass Spec Problems April NOTE: It is not my intent to try to turn the readers into mass spec service technicians. I provide this information to help educate the readers. I realize that it’s a full time job just to run a GC/MS-what with tuning, calibrating, running samples, reviewing data, etc. Sensitivity of a particular instrument depends on the analyte and its matrix, the method of separation, the method of ionization and the mass spectrometer. With this knowledge, we were able to determine relative sensitivity factors for the metals on UV/ozone‐treated Si wafer surfaces measured by TOF‐SIMS. Detection limits down to 10 8 cm −2 and 10 12 cm −2 for sample surface areas of μm in diameter and 1 μm in diameter, respectively, were found for both Laser‐SNMS and TOF‐ by: Resonance ionization is a process in optical physics used to excite a specific atom (or molecule) beyond its ionization potential to form an ion using a beam of photons irradiated from a pulsed laser light. In resonance ionization, the absorption or emission properties of the emitted photons are not considered, rather only the resulting excited ions are mass-selected, detected and measured.

absorbed dose \(D\) accuracy acidity constant acid–base indicator activation analysis (nuclear) activation cross-section active solid additive additivity adsorbate adsorbent adsorption adsorption chromatography adsorption indicator after mass analysis ageing of precipitate amphiprotic (solvent) amplitude of alternating current annihilation. CHROMATOGRAPHIA highlights new and fundamental developments in separation technologies and approaches, sorbent materials, mobile phases, sample preparation methods, and detection techniques, which improve the sensitivity, selectivity, efficiency and speed of separations. this is known as “sensitivity” and is an important characteristic. However, sensitivity is not, by itself, sufficient to predict detection limits. For example, if contamination is present, a fold increase in signal will also increase the background fold. In an ideal situation (i.e. the absence of high background or excessive noise)File Size: 1MB. @article{osti_, title = {Determination of isotopic thorium in biological samples by combined alpha spectrometry and neutron activation analysis.}, author = {Glover, S E}, abstractNote = {Thorium is a naturally occurring element for whom all isotopes are radioactive. Many of these isotopes are alpha emitting radionuclides, some of which have limits for inhalation lower than plutonium in.

LABORATORY DOCUMENTATION REQUIRED FOR DATA EVALUATION USEPA Region IX Quality Assurance Office San Francisco, California R9QA/ Emission / Mass Spectrometry Interference Check Samples Precision and Accuracy relative response factors (RRF), or calibration factors (CF), percent relative standard File Size: KB. Mass spectrometry (MS) is an analytical laboratory technique to separate the components of a sample by their mass and electrical charge. The instrument used in MS is called mass spectrometer. It produces a mass spectrum that plots the mass-to-charge (m/z) ratio of compounds in a mixture. Before sending a sample, please use the mass spectrometry sample submission form to alert us for the arrival of the sample. Concurrently, a printed copy of the mass spectrometry sample submission form should accompany the sample. This form is available on this website and can be filled out online. Ship the sample to: Bio-Synthesis Inc. Relative to 12 C at , the isotopic mass of 16 O is amu., etc. High resolution mass spectrometers that can determine m/z values accurately to four/more decimal places, making it possible to distinguish different molecular formulas having the same nominal mass. MF Unsaturation Exact Mass C2H2O3 CH 2N2O2 File Size: 2MB.

Determination of relative sensitivity factors for use in spark-source mass spectrometry by D.C.G. Pearton Download PDF EPUB FB2

Relative Sensitivity Factors (RSFs) for the rare earth elements Ce, Nd, Sm, Eu, Gd, Dy, Er and Lu in U3O8 have been determined by Spark Source Mass Spectrometry (SSMS) using the electrical detection system in peak switching by: 8.

Relative sensitivity factors for determination of 41 elements by spark-source mass-spectrometry have been measured. The samples were pressed into graphite electrodes and ionized with a radiofrequency by: 9. The object of the work described in this paper was to make a preliminary survey of the method and application of spark source mass spectrometry to the analysis of impurities in solids, using a double focusing instrument specially designed for this problem.

DETERMINATION OF IMPURITIES IN SOLIDS by: Spark source mass spectrometry is one of the most sensitive techniques available for routine trace-element analysis of geological samples. Determinations down to the parts per billion level are possible with virtually no preparation of the sample other than crushing it to a fine particle size and compressing it with graphite to make a suitable by: 6.

Relative Sensitivity Factors for Rare Earth Elements in Different Matrices Employing Spark Source Mass Spectrometry. Spectroscopy Letters: Vol. 18, No. 7, pp. Cited by: 1. For quantitative information using secondary ion mass spectrometry (SIMS), so-called relative sensitivity factors (RSF) are mandatory.

Such conversion factors did not yet exist for ZnO. In this work, we present the determined RSF values for ZnO using primary (ion implanted) as well as secondary (bulk doped) standards. Only in a few papers on spark-source mass spectrometry has the matrix influence not been discovered [12,13].

3 Conditions of spark discharge or laser radiation interaction with the sample The RSC values are known to depend on such experimental conditions as position of the plasma generation site relative to the ion-optical system [15], discharge duration [, the current through the discharge gap Cited by: The sensitivity of spark-source mass spectrometric analysis for various trace elements differs remarkably.

In order to correct such different sensi- tivities, it is common to use a relative sensitivity factor (r.s.f.) which is a sensitivity ratio for a measured element and a matrix or other by:   The relative sensitivity factors (RSFs) of 68 elements in inductively coupled plasma mass spectrometry were determined.

The ionization process in an inductively coupled plasma was found to be only approximately described by the Saha–Eggert equation. A relationship between the RSFs and the absolute electronegativities of atoms was found. This factor has the strongest effect on the Cited by: 5.

Mass spectrometry is widely used in analytical chemistry and biochemistry, and is making new inroads into the biomedical and clinical fields. Mass spectrometry offer several advantages such as it is accurate and robust enough to be widely used as in the pharmaceutical industry, and it.

It was also shown that for relatively acidic compounds, particularly for corroles, the negative ion mode provides better sensitivity than the positive ion mode. The results supply a lot of relevant information on the methodology of porphyrinoids analysis carried out by mass by: 6.

Mass spectrometry 88 Spark source mass spectrometry 89 Glow-­‐discharge mass spectrometry 89 Inductively coupled plasma-­‐mass spectrometry 90 Neutron activation analysis 91 Instrumental neutron activation analysis 92 Prompt-­‐gamma neutron.

Sensitivity of mass spectrometry analysis depends on the shape of the filtration unit used for filter aided sample preparation (FASP) Joanna Lipecka. The CPN Proteomics Facility – 3P5, Center of Psychiatry and Neuroscience, UMR INSERMParis, by: Spark source mass spectrometry (SSMS), the paternal multielement mass spectrometric technique, refuses to yield completely to the newer techniques and was still in use in a surprising number of.

Liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) are analytical techniques that have often been used in metabolomics studies to generate the high content data. Another important component is to apply multivariate statistical techniques to analyze the MS-based metabolomics by: Mass spectrometry (MS) is an analytical technique that measures the mass-to-charge ratio of ions.

The results are typically presented as a mass spectrum, a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures.

Although the analysis of thermal water by spark-source mass spectrometry (SSMS) is rather timeconsuming, it allows the detection of about 20 elements of geochemical interest down to the ppb-level.

A physical preconcentration is proposed in order to collect elements having quite different chemical properties, e.g. alkalis, transition elements, and elements occurring in anionic by: 7. Mass Spectrometry: Detectors Review Article (PDF Available) in Annual Review of Chemical and Biomolecular Engineering 3(4) October with 6, Reads How we measure 'reads'.

J Mass Spectrom. Oct;48(10) doi: /jms Comparison of the sensitivity of mass spectrometry atmospheric pressure ionization techniques in the analysis of porphyrinoids.

Swider P(1), Lewtak JP, Gryko DT, Danikiewicz by: 6. Signal, Noise, and Detection Limits in Mass Spectrometry Technical Note Abstract In the past, the signal-to-noise of a chromatographic peak determined from a single measurement has served as a convenient figure of merit used to compare the perfor-mance of two different MS systems.

Design evolution of mass spectrometry instru. Secondary ion mass spectrometry has the potential for high spatial resolution surface analysis of polymers via fingerprint mass spectra and the use of a focused ion beam. Sensitivity, A; Slope of the calibration curve.

Note 1: If the curve is not a straight line, sensitivity will be a function of analyte concentration or amount. Note 2: If sensitivity is to be a unique performance characteristic, it must depend only on the chemical measurement process, not upon scale factors.

Related Term(s): Reference(s): IUPAC. Analytical Division. If an ion has a mass of 36 units and a 2+ charge, its m/z value is also Most of the ions moving from the ionization chamber to the mass analyzer have lost a single electron, so they have a charge of 1+.

That means the m/z value of most ions passing through a mass spectrometer is the same as the mass. Mass spectrometry is a powerful technique in analytical chemistry that was originally designed to determine the composition of small molecules in terms of their constituent elements.

In the last several decades, it has begun to be used for much more complex tasks, including the detailed analysis of File Size: 1MB. Three methods of detecting and recording spectra are described and the relative merits of each discussed.

Sample ashing techniques are also described. Spark source mass spectrometry is compared with emission spectroscopy and atomic absorption spectrophotometry as applied to the analysis of biological materials. Mass spectrometry is a sensitive technique used to detect, identify and quantitate molecules based on their mass-to-charge (m/z) ratio.

Originally developed almost years ago to measure elemental atomic weights and the natural abundance of specific isotopes, MS was first used in the biological sciences to trace heavy isotopes through. Various mass-spectrometric possibilities are briefly discussed: ionization techniques, determination of elemental formulas, structural information and the question of sensitivity and selectivity.

Options for mass-spectrometric instrumentation and applications of tandem mass spectrometry are also mentioned. Elsevier Science B.V. All rightsFile Size: KB. • A mass spectrum is the plot of relative abundance of ions against their mass/charge ratio. • The basic aspect of organic mass spectrometry consist of bombarding the vapour of an organic compound with a beam of energetic electron accelerated from a filament to an energy of 70 eV to form positively charged ions (molecular ions).

Relative sensitivity factors for the determination of rare earth elements in uranium oxide by Spark Source Mass Spectrometry E - 92() Standard Guide for Determining SIMS Relative Sensitivity Factors from Ion Implanted External Standards, SIMS. Determination of Trace Amounts of Carbon, Nitrogen and Oxygen in Steel by Glow Discharge Mass Spectrometry.

Tetsu-to-Hagane77 (11), DOI: /tetsutohagane_ Wojciech Vieth, John C. Huneke. Relative sensitivity factors in glow discharge mass by:. Mass spectroscopy pdf 1. CONTENTS: 2. INTRODUCTION Mass spectrometry (MS) is an analytical technique that measures the mass-to-charge particles.

It is used for determining masses of particles, for determining the elemental composition of a sample or molecule.peptides (1). For decades, mass spectrometry has also served for determining the absolute or relative amounts of components of complex matrices. There are countless reports on absolute quantification of target molecules by external or internal standards, often by use File Size: KB.

mass spectrometry 1. mass spectrometry submitted by: princy agarwal m. pharma. [quality assurance] 2. contents introduction history principle mass spectrometer components of mass spectrometer esi [electrospray ionization] maldi [matrix assisted laser seorption ionization] fab [fast atom bombardment] field desorption plasma desorption apci [atmospheric pressure chemical ionization] .